/* Trial Cards Components */
.trials-grid {
  display: grid;
  grid-template-columns: minmax(0, 1fr);
  gap: 1rem;
}

.trial-card {
  --trial-accent: #94a3b8;
  background: linear-gradient(180deg, #ffffff 0%, #fbfdff 100%);
  border-radius: 22px;
  padding: 1.2rem 1.2rem 1.1rem;
  box-shadow: 0 20px 38px -30px rgba(15, 23, 42, 0.32);
  border: 1px solid rgba(148, 163, 184, 0.24);
  transition: transform 0.22s ease, box-shadow 0.22s ease, border-color 0.22s ease;
  cursor: pointer;
  position: relative;
  overflow: hidden;
}

.trial-card::before {
  content: "";
  position: absolute;
  inset: 0 auto 0 0;
  width: 4px;
  background: linear-gradient(180deg, var(--trial-accent) 0%, rgba(255, 255, 255, 0.18) 100%);
}

.trial-card::after {
  content: "";
  position: absolute;
  top: -4rem;
  right: -3rem;
  width: 9rem;
  height: 9rem;
  border-radius: 50%;
  background: radial-gradient(circle, rgba(255, 255, 255, 0.92) 0%, rgba(255, 255, 255, 0) 70%);
  pointer-events: none;
  opacity: 0.9;
}

.trial-card:hover {
  transform: translateY(-3px);
  box-shadow: 0 28px 46px -30px rgba(15, 23, 42, 0.4);
  border-color: rgba(37, 99, 235, 0.25);
}

.trial-card--recruiting {
  --trial-accent: #119669;
}

.trial-card--active-not-recruiting {
  --trial-accent: #2563eb;
}

.trial-card--completed,
.trial-card--not-specified {
  --trial-accent: #64748b;
}

.trial-card--match-strong {
  --trial-accent: #15803d;
}

.trial-card--match-possible {
  --trial-accent: #d97706;
}

.trial-card--patient-search {
  background: linear-gradient(180deg, #ffffff 0%, #f8fbff 100%);
}

.trial-card-topline {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 0.75rem;
  margin-bottom: 0.95rem;
}

.trial-card-chips,
.trial-card-topline-right,
.trial-source-tags,
.trial-card-actions {
  display: flex;
  align-items: center;
  flex-wrap: wrap;
  gap: 0.45rem;
}

.trial-meta-chip {
  display: inline-flex;
  align-items: center;
  min-height: 1.75rem;
  padding: 0.25rem 0.6rem;
  border-radius: 999px;
  background: #eff4fb;
  border: 1px solid rgba(148, 163, 184, 0.18);
  color: #334155;
  font-size: 0.68rem;
  font-weight: 700;
  letter-spacing: 0.04em;
  text-transform: uppercase;
}

.trial-card-header {
  display: block;
  margin-bottom: 1rem;
  width: 100%;
}

.trial-title-wrap {
  width: 100%;
  max-width: none;
}

.trial-title {
  font-family: "Iowan Old Style", "Palatino Linotype", "Book Antiqua", Georgia, serif;
  font-size: 1.18rem;
  font-weight: 700;
  letter-spacing: -0.01em;
  color: var(--text-primary);
  line-height: 1.3;
  margin: 0;
  max-width: none;
}

.trial-status {
  display: inline-flex;
  align-items: center;
  min-height: 1.8rem;
  padding: 0.28rem 0.72rem;
  border-radius: 999px;
  font-size: 0.68rem;
  font-weight: 800;
  text-transform: none;
  letter-spacing: 0.03em;
  white-space: nowrap;
  flex-shrink: 0;
  border: 1px solid transparent;
}

.trial-status.recruiting,
.trial-status.ongoing {
  background-color: #dcfce7;
  color: #166534;
  border-color: rgba(34, 197, 94, 0.16);
}

.trial-status.active-not-recruiting,
.trial-status.upcoming {
  background-color: #dbeafe;
  color: #1e40af;
  border-color: rgba(59, 130, 246, 0.18);
}

.trial-status.completed,
.trial-status.past {
  background-color: #f3f4f6;
  color: #374151;
  border-color: rgba(148, 163, 184, 0.2);
}

.trial-status.not-specified {
  background-color: #f1f5f9;
  color: #334155;
  border-color: rgba(148, 163, 184, 0.2);
}

.trial-match-pill {
  display: inline-flex;
  align-items: center;
  min-height: 1.8rem;
  padding: 0.28rem 0.72rem;
  border-radius: 999px;
  font-size: 0.68rem;
  font-weight: 800;
  letter-spacing: 0.03em;
  border: 1px solid transparent;
}

.trial-match-pill--strong {
  background: #dcfce7;
  color: #166534;
  border-color: rgba(22, 163, 74, 0.16);
}

.trial-match-pill--possible {
  background: #fef3c7;
  color: #92400e;
  border-color: rgba(245, 158, 11, 0.22);
}

.trial-description {
  color: var(--text-secondary);
  font-size: 0.92rem;
  line-height: 1.55;
  margin: 0.55rem 0 0;
  display: -webkit-box;
  -webkit-line-clamp: 2;
  -webkit-box-orient: vertical;
  overflow: hidden;
}

.trial-qualification {
  background-color: #f8fafc;
  padding: 0.75rem;
  border-radius: var(--border-radius);
  border-left: 3px solid var(--primary-color);
  margin-bottom: 1rem;
}

.trial-qualification-label {
  font-size: 0.75rem;
  font-weight: 600;
  color: var(--text-secondary);
  text-transform: uppercase;
  letter-spacing: 0.025em;
  margin-bottom: 0.25rem;
}

.trial-qualification-text {
  font-size: 0.875rem;
  color: var(--text-primary);
  line-height: 1.4;
  display: -webkit-box;
  -webkit-line-clamp: 2;
  -webkit-box-orient: vertical;
  overflow: hidden;
}

.trial-details {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 0.65rem;
}

.trial-card-extras {
  display: grid;
  gap: 0.75rem;
}

.trial-detail-card {
  display: flex;
  align-items: flex-start;
  gap: 0.72rem;
  font-size: 0.875rem;
  padding: 0.78rem 0.82rem;
  border-radius: 16px;
  border: 1px solid rgba(226, 232, 240, 0.95);
  background: linear-gradient(180deg, #f9fbff 0%, #f7fafe 100%);
}

.trial-detail-icon {
  width: 2rem;
  height: 2rem;
  border-radius: 14px;
  background: #ffffff;
  border: 1px solid rgba(148, 163, 184, 0.2);
  color: var(--trial-accent);
  display: inline-flex;
  align-items: center;
  justify-content: center;
  flex-shrink: 0;
}

.trial-icon {
  width: 1rem;
  height: 1rem;
}

.trial-detail-content {
  flex: 1;
  min-width: 0;
}

.trial-detail-label {
  font-weight: 700;
  color: var(--text-secondary);
  margin-bottom: 0.2rem;
  display: block;
  font-size: 0.68rem;
  text-transform: uppercase;
  letter-spacing: 0.045em;
}

.trial-detail-value {
  color: var(--text-primary);
  line-height: 1.35;
  font-size: 0.86rem;
  font-weight: 600;
}

.trial-detail-subvalue {
  color: var(--text-secondary);
  line-height: 1.4;
  font-size: 0.75rem;
  margin-top: 0.16rem;
}

.trial-location {
  font-weight: 500;
}

.trial-contact {
  color: var(--primary-color);
  text-decoration: none;
  transition: color 0.2s ease;
}

.trial-contact:hover {
  color: var(--primary-hover);
  text-decoration: underline;
}

.trial-card-footer {
  margin-top: 1.05rem;
  padding-top: 0.95rem;
  border-top: 1px solid rgba(226, 232, 240, 0.95);
  display: flex;
  justify-content: space-between;
  align-items: flex-end;
  gap: 0.9rem;
}

.trial-dates {
  display: flex;
  align-items: center;
  flex-wrap: wrap;
  gap: 0.55rem;
  font-size: 0.75rem;
  color: var(--text-secondary);
  flex: 1;
}

.trial-date-item {
  display: inline-flex;
  flex-wrap: wrap;
  gap: 0.3rem;
  align-items: center;
}

.trial-date-label {
  font-size: 0.68rem;
  font-weight: 800;
  letter-spacing: 0.04em;
  text-transform: uppercase;
  color: #64748b;
}

.trial-date-value {
  color: #334155;
  font-weight: 600;
}

.trial-view-btn {
  padding: 0.62rem 0.95rem;
  background-color: var(--primary-color);
  color: white;
  border: none;
  border-radius: 999px;
  font-size: 0.84rem;
  font-weight: 700;
  cursor: pointer;
  transition: background-color 0.2s ease, transform 0.2s ease, border-color 0.2s ease, color 0.2s ease;
  text-decoration: none;
  display: inline-flex;
  align-items: center;
  justify-content: center;
  min-height: 2.25rem;
}

.trial-view-btn:hover {
  background-color: var(--primary-hover);
  transform: translateY(-1px);
}

.trial-view-btn--ghost {
  background: #ffffff;
  color: var(--primary-color);
  border: 1px solid rgba(148, 163, 184, 0.28);
}

.trial-view-btn--ghost:hover {
  background: #eff6ff;
  color: var(--primary-hover);
  border-color: rgba(37, 99, 235, 0.24);
}

.trial-match-reason {
  margin-top: 0;
  padding: 0.9rem 1rem;
  border-radius: 16px;
  border: 1px solid rgba(148, 163, 184, 0.18);
  background: linear-gradient(180deg, #f8fbff 0%, #f3f8ff 100%);
}

.trial-match-reason--strong {
  background: linear-gradient(180deg, #f2fbf5 0%, #eefaf2 100%);
  border-color: rgba(34, 197, 94, 0.18);
}

.trial-match-reason--possible {
  background: linear-gradient(180deg, #fffaf0 0%, #fff7e6 100%);
  border-color: rgba(245, 158, 11, 0.22);
}

.trial-match-reason-label {
  display: inline-block;
  margin-bottom: 0.35rem;
  font-size: 0.7rem;
  font-weight: 800;
  letter-spacing: 0.05em;
  text-transform: uppercase;
  color: #475569;
}

.trial-match-reason p {
  margin: 0;
  color: var(--text-primary);
  font-size: 0.88rem;
  line-height: 1.5;
}

.trial-flag-list {
  display: grid;
  gap: 0.55rem;
  margin-top: 0;
}

.trial-flag-card {
  padding: 0.82rem 0.95rem;
  border: 1px solid #fde68a;
  background: linear-gradient(180deg, #fffcf0 0%, #fff7df 100%);
  border-radius: 16px;
}

.trial-flag-title {
  font-size: 0.76rem;
  font-weight: 800;
  color: #92400e;
  margin-bottom: 0.22rem;
  letter-spacing: 0.02em;
}

.trial-flag-message {
  font-size: 0.82rem;
  color: #78350f;
  line-height: 1.45;
}

.trial-source-tags {
  margin-top: 0;
}

.trial-source-tag {
  display: inline-flex;
  align-items: center;
  min-height: 1.7rem;
  padding: 0.22rem 0.55rem;
  border-radius: 999px;
  border: 1px solid rgba(148, 163, 184, 0.22);
  background: #ffffff;
  color: var(--text-secondary);
  font-size: 0.69rem;
  font-weight: 700;
  letter-spacing: 0.02em;
}

@media (min-width: 1100px) {
  .trial-details {
    grid-template-columns: repeat(4, minmax(0, 1fr));
  }
}

/* Status Indicators */
.status-indicator {
  position: relative;
  padding-left: 1rem;
}

.status-indicator::before {
  content: '';
  position: absolute;
  left: 0;
  top: 50%;
  transform: translateY(-50%);
  width: 8px;
  height: 8px;
  border-radius: 50%;
}

.status-indicator.recruiting::before,
.status-indicator.ongoing::before {
  background-color: var(--success-color);
  box-shadow: 0 0 6px rgba(16, 185, 129, 0.4);
}

.status-indicator.active-not-recruiting::before,
.status-indicator.upcoming::before {
  background-color: var(--primary-color);
  box-shadow: 0 0 6px rgba(37, 99, 235, 0.4);
}

.status-indicator.completed::before,
.status-indicator.past::before {
  background-color: var(--secondary-color);
}

.status-indicator.not-specified::before {
  background-color: #64748b;
}

/* Pagination */
.pagination {
  display: flex;
  justify-content: center;
  align-items: center;
  gap: 0.5rem;
  margin-top: 2rem;
  padding: 1.5rem;
}

.pagination-btn {
  padding: 0.5rem 0.75rem;
  border: 1px solid var(--border-color);
  background-color: var(--card-background);
  color: var(--text-primary);
  border-radius: var(--border-radius);
  cursor: pointer;
  font-size: 0.875rem;
  transition: all 0.2s ease;
}

.pagination-btn:hover:not(:disabled) {
  border-color: var(--primary-color);
  color: var(--primary-color);
}

.pagination-btn.active {
  background-color: var(--primary-color);
  color: white;
  border-color: var(--primary-color);
}

.pagination-btn:disabled {
  opacity: 0.5;
  cursor: not-allowed;
}

.pagination-info {
  color: var(--text-secondary);
  font-size: 0.875rem;
  margin: 0 1rem;
}

/* Form Components */
.form-group {
  margin-bottom: 1.5rem;
}

.form-label {
  display: block;
  font-weight: 500;
  color: var(--text-primary);
  margin-bottom: 0.5rem;
  font-size: 0.875rem;
}

.form-input,
.form-textarea,
.form-select {
  width: 100%;
  padding: 0.75rem;
  border: 1px solid var(--border-color);
  border-radius: var(--border-radius);
  background-color: var(--card-background);
  color: var(--text-primary);
  font-size: 0.875rem;
  transition: border-color 0.2s ease;
}

.form-input:focus,
.form-textarea:focus,
.form-select:focus {
  outline: none;
  border-color: var(--primary-color);
  box-shadow: 0 0 0 3px rgba(37, 99, 235, 0.1);
}

.form-textarea {
  resize: vertical;
  min-height: 100px;
}

.form-error {
  color: var(--error-color);
  font-size: 0.75rem;
  margin-top: 0.25rem;
}

.form-help {
  color: var(--text-secondary);
  font-size: 0.75rem;
  margin-top: 0.25rem;
}

/* Button Components */
.btn {
  padding: 0.75rem 1.5rem;
  border-radius: var(--border-radius);
  font-weight: 500;
  font-size: 0.875rem;
  border: none;
  cursor: pointer;
  text-decoration: none;
  display: inline-block;
  text-align: center;
  transition: all 0.2s ease;
}

.btn-primary {
  background-color: var(--primary-color);
  color: white;
}

.btn-primary:hover {
  background-color: var(--primary-hover);
}

.btn-secondary {
  background-color: var(--secondary-color);
  color: white;
}

.btn-secondary:hover {
  background-color: #475569;
}

.btn-outline {
  background-color: transparent;
  color: var(--primary-color);
  border: 1px solid var(--primary-color);
}

.btn-outline:hover {
  background-color: var(--primary-color);
  color: white;
}

.btn-danger {
  background-color: var(--error-color);
  color: white;
}

.btn-danger:hover {
  background-color: #dc2626;
}

/* Alert Components */
.alert {
  padding: 1rem;
  border-radius: var(--border-radius);
  margin-bottom: 1rem;
  font-size: 0.875rem;
}

.alert-success {
  background-color: #d1fae5;
  color: #065f46;
  border: 1px solid #a7f3d0;
}

.alert-error {
  background-color: #fee2e2;
  color: #991b1b;
  border: 1px solid #fca5a5;
}

.alert-warning {
  background-color: #fef3c7;
  color: #92400e;
  border: 1px solid #fcd34d;
}

.alert-info {
  background-color: #dbeafe;
  color: #1e40af;
  border: 1px solid #93c5fd;
}

/* Modal Components */
.modal {
  display: none;
  position: fixed;
  top: 0;
  left: 0;
  width: 100%;
  height: 100%;
  background-color: rgba(0, 0, 0, 0.5);
  z-index: 1000;
}

.modal.active {
  display: flex;
  align-items: center;
  justify-content: center;
}

.modal-content {
  background-color: var(--card-background);
  border-radius: var(--border-radius);
  padding: 2rem;
  max-width: 90vw;
  max-height: 90vh;
  overflow-y: auto;
  box-shadow: var(--shadow-lg);
}

.modal-header {
  display: flex;
  justify-content: space-between;
  align-items: center;
  margin-bottom: 1.5rem;
}

.modal-title {
  font-size: 1.25rem;
  font-weight: 600;
  color: var(--text-primary);
}

.modal-close {
  background: none;
  border: none;
  font-size: 1.5rem;
  cursor: pointer;
  color: var(--text-secondary);
  padding: 0.25rem;
  border-radius: var(--border-radius);
  transition: all 0.2s ease;
}

.modal-close:hover {
  background-color: #f1f5f9;
  color: var(--text-primary);
}

/* Responsive Adjustments for Components */
@media (max-width: 768px) {
  .trials-grid {
    grid-template-columns: 1fr;
    gap: 1rem;
  }

  .trial-card {
    padding: 1rem;
  }

  .trial-card-topline,
  .trial-card-footer {
    flex-direction: column;
    align-items: flex-start;
  }

  .trial-card-topline-right,
  .trial-card-actions {
    width: 100%;
  }

  .trial-details {
    grid-template-columns: 1fr;
  }

  .pagination {
    flex-wrap: wrap;
    gap: 0.25rem;
  }

  .modal-content {
    margin: 1rem;
    padding: 1.5rem;
  }
}

@media (max-width: 480px) {
  .trial-card {
    padding: 1rem;
  }

  .trial-card-topline-right,
  .trial-card-actions {
    align-items: stretch;
  }

  .trial-view-btn {
    width: 100%;
    text-align: center;
  }

  .btn {
    width: 100%;
  }
}